Midkiff is a small rural community located in Upton County, Texas. The climate in Midkiff is characterized as a semi-arid desert type, with hot summers and mild winters. Summers are scorching, with temperatures often exceeding 100°F (38°C), while winters are relatively mild, with average temperatures around 50°F (10°C). Precipitation is scarce, averaging around 14 inches (36 cm) per year, mostly occurring in the form of brief but intense thunderstorms during the summer months.

In terms of hydrology, Midkiff is situated in an arid region with limited water sources. The area relies heavily on groundwater for its water supply, with the Trinity Aquifer being the primary source. However, due to the arid nature of the region, water conservation is essential.

Despite its arid environment, Midkiff offers several outdoor recreation opportunities. The nearby Upton County Park provides a scenic setting for camping, picnicking, and hiking. Hunting enthusiasts can enjoy pursuing game such as white-tailed deer, wild turkey, and dove in the surrounding countryside. Additionally, the area's vast open spaces are perfect for off-road enthusiasts, making Midkiff a popular destination for off-roading and ATV adventures.