Poplar Bluff, Missouri is located in the southeastern part of the state, characterized by a humid subtropical climate. Summers in Poplar Bluff are hot and humid, with temperatures averaging around 90°F (32°C) and occasional thunderstorms. Winters are typically mild, with temperatures ranging between 30°F (-1°C) and 50°F (10°C). The area experiences moderate rainfall throughout the year.

The city of Poplar Bluff is situated near the Black River, which provides hydrology constituents to the region. The river offers opportunities for fishing, boating, and other water-based activities.

Outdoor enthusiasts in Poplar Bluff can explore the scenic Mark Twain National Forest located nearby. The forest provides ample opportunities for hiking, camping, hunting, and wildlife viewing. The region is also home to several parks and recreational areas, including Lake Wappapello State Park, which offers activities such as fishing, swimming, boating, and camping. The area's natural beauty and diverse outdoor recreation opportunities make Poplar Bluff an attractive destination for nature lovers and adventure seekers.