Puxico, Missouri is a small town located in Stoddard County in the southeastern part of the state. The climate in Puxico is characterized by hot, humid summers and mild to cool winters. Average temperatures range from 31°F (-1°C) in January to 89°F (32°C) in July. The area receives about 43 inches (109 cm) of precipitation annually, with rainfall fairly evenly distributed throughout the year.

Puxico is surrounded by various bodies of water, including Duck Creek, Mingo National Wildlife Refuge, and Lake Wappapello. These hydrological constituents provide excellent opportunities for outdoor recreation. Duck Creek Conservation Area offers fishing, boating, and wildlife viewing, while Mingo National Wildlife Refuge is a haven for birdwatchers and nature enthusiasts. Lake Wappapello, located about 15 miles south of Puxico, is a popular spot for fishing, boating, and camping.

Visitors to Puxico can also explore the town's scenic parks and hiking trails, such as the Puxico City Park and the nearby Mingo Trail. These natural settings, combined with the town's welcoming community, make Puxico an ideal destination for outdoor enthusiasts seeking a peaceful and refreshing retreat.