Tillatoba is a small town located in Yalobusha County, Mississippi. The town experiences a humid subtropical climate, characterized by hot, humid summers and mild winters. Summers are usually long and humid, with temperatures often reaching the 90s°F (30s°C), while winters are milder, with average temperatures in the 40s°F (5-10°C). Precipitation is fairly evenly distributed throughout the year, with slightly more rainfall occurring during the spring and early summer months.

Hydrologically, Tillatoba is situated near Tillatoba Lake, a 2,300-acre freshwater lake that offers various recreational activities such as boating, fishing, and camping. The lake is home to a variety of fish species, including bass, crappie, and catfish, attracting many anglers. The surrounding natural environment provides opportunities for bird-watching and wildlife observation.

In addition to Tillatoba Lake, the nearby Enid Lake and Grenada Lake also offer additional outdoor recreation opportunities, including swimming, water skiing, hiking, and hunting. These lakes, along with the beautiful countryside, draw visitors who enjoy exploring the natural beauty and engaging in various outdoor activities.