Wetmore, Colorado is a small town nestled in the Wet Mountains region of the state. The town experiences a semi-arid climate with mild winters and warm summers. The average annual temperature is around 54°F, with temperatures ranging from the mid-30s in winter to the mid-80s in summer. Precipitation is moderate, averaging around 20 inches per year, with most of it falling during the summer months.

The hydrology constituents in Wetmore are primarily influenced by the nearby Arkansas River. The river provides a source of water for irrigation and supports a diverse range of aquatic life. Wetmore is also surrounded by several creeks and streams, adding to the local hydrological system.

Outdoor enthusiasts will find several recreational opportunities in Wetmore. The region offers great hiking and camping opportunities, with the nearby San Isabel National Forest providing ample trails and campsites. Fishing is popular in the Arkansas River and local lakes, where anglers can catch various species such as trout and bass. Hunting is another popular activity, with plentiful opportunities for deer and elk hunting in the surrounding forests. Wildlife viewing, birdwatching, and photography are also favored activities due to the town's picturesque landscapes and abundant wildlife.