The Whitewater River Run South Branch originates in Section 25, T38N, R14E, and flows until it joins the Main Branch in Wisconsin. The ideal streamflow range for this river is between 100 and 500 cfs, making it ideal for kayakers and experienced white water rafters. The class rating of this river is between II and IV, meaning it is suitable for intermediate to advanced level white water enthusiasts. The segment mileage of this river run is approximately 10 miles, making it a reasonable day trip for paddlers.

There are several notable rapids and obstacles along the route, such as the "Rock Garden," which is a tight section of the river with several small boulders to navigate around, and "Twin Sisters," which is a pair of back-to-back class III rapids. Additionally, there are several narrow sections of the river that require precise maneuvering to avoid obstacles.

It is important to note that there are specific regulations in place for the Whitewater River Run South Branch. Paddlers must wear a personal flotation device at all times, and camping is only allowed in designated areas. Additionally, paddlers must be aware of private property along the river and respect the landowners' rights.