Whetstone Run is a small stream located in Mannington, West Virginia. Its history dates back to the early 1900s when it was used for agricultural purposes, including irrigation and watering livestock. Hydrologically, Whetstone Run is a tributary of Buffalo Creek, which eventually empties into the Monongahela River. The stream is fed by specific surface flows and snowpack during the winter months. The surrounding area is primarily agricultural, with some recreational activities such as fishing and hiking. In recent years, there have been concerns about water quality due to increased pollution from nearby mining and drilling operations. Efforts have been made to monitor and improve the stream's condition, including the installation of water treatment facilities.