Total streamflow across the Guyandotte River was last observed at 560 cfs, and is expected to yield approximately 1,111 acre-ft of water today; about 64% of normal. River levels are low and may signify a drought. Average streamflow for this time of year is 869 cfs, with recent peaks last observed on 2015-03-05 when daily discharge volume was observed at 30,900 cfs.

Maximum discharge along the river is currently at the Guyandotte River At Man reporting a streamflow rate of 968 cfs. This is also the highest stage along the Guyandotte River, with a gauge stage of 6.12 ft at this location. This river is monitored from 3 different streamgauging stations along the Guyandotte River, the highest being situated at an altitude of 1,139 ft, the Guyandotte River Near Baileysville.

The Guyandotte River is located in West Virginia, stretching over 160 miles from its headwaters in Wyoming County to its confluence with the Ohio River in Huntington. The river has played a significant role in the state's history, serving as a major transportation route for timber and coal during the late 19th and early 20th centuries. The river is also home to several reservoirs, including the Guyandotte Reservoir, R.D. Bailey Lake, and East Lynn Lake, which provide flood control and recreational opportunities such as boating and fishing. However, these reservoirs have also had negative impacts on the river's hydrology and water quality. In recent years, efforts have been made to improve these issues and promote sustainable agricultural practices along the river's banks.