Total streamflow across the Nisqually River was last observed at 2,001 cfs, and is expected to yield approximately 3,969 acre-ft of water today; about 90% of normal. Average streamflow for this time of year is 2,228 cfs, with recent peaks last observed on 2020-02-06 when daily discharge volume was observed at 42,400 cfs.

Maximum discharge along the river is currently at the Nisqually River At La Grande reporting a streamflow rate of 861 cfs. However, the streamgauge with the highest stage along the river is the Nisqually River Near National with a gauge stage of 4.92 ft. This river is monitored from 4 different streamgauging stations along the Nisqually River, the highest being situated at an altitude of 1,436 ft, the Nisqually River Near National.

The Nisqually River runs 78 miles from the Nisqually Glacier on Mount Rainier to southern Puget Sound. The river was historically home to the Nisqually tribe, and was an important source of food and transportation. Today, the river and its watershed are managed by the Nisqually Indian Tribe, Nisqually National Wildlife Refuge, and local governments. The hydrology of the river is influenced by seasonal snowmelt and precipitation. There are two major reservoirs on the river, Alder Dam and LaGrande Dam, which are used for hydroelectric power generation and water supply. The river is also used for recreational activities such as fishing, kayaking, and rafting. Agricultural uses include pastureland and crops such as berries and vegetables. Efforts to restore and protect the river and its habitats are ongoing.