Maximum discharge along the river is currently at the reporting a streamflow rate of cfs. This is also the highest stage along the Oconaluftee River, with a gauge stage of ft at this location. This river is monitored from 1 different streamgauging stations along the Oconaluftee River, the highest being situated at an altitude of ft, the .
The Oconaluftee River drains the south-central Oconaluftee valley of the Great Smoky Mountains in North Carolina before emptying into the Tuckasegee River. The river flows through the Qualla Boundary, a federal land trust that acts as a reservation for the Eastern Band of the Cherokee.