Total streamflow across the Santee River was last observed at 11,541 cfs, and is expected to yield approximately 22,891 acre-ft of water today; about 89% of normal. Average streamflow for this time of year is 13,003 cfs, with recent peaks last observed on 2016-01-05 when daily discharge volume was observed at 166,900 cfs.

Maximum discharge along the river is currently at the Santee River Nr Jamestown reporting a streamflow rate of 10,900 cfs. This is also the highest stage along the Santee River, with a gauge stage of 7.45 ft at this location. This river is monitored from 2 different streamgauging stations along the Santee River, the highest being situated at an altitude of 25 ft, the Santee River Near Pineville.

The Santee River is a 143-mile-long blackwater river in South Carolina. The river has a rich history, having played a role in the American Revolution and the Civil War. It is the second-longest river in the state and flows into the Atlantic Ocean. The hydrology of the river is unique, as it is a blackwater river due to high levels of tannic acid in the water. The river is also known for its diverse fish population. Specific reservoirs and dams along the river include the Lake Marion Dam and Lake Moultrie Dam. These reservoirs are used for hydroelectric power generation and flood control. The river also has recreational uses, including fishing and boating, and is an important source of irrigation for agriculture in the surrounding areas.