Total streamflow across the Tuckasegee River was last observed at 1,829 cfs, and is expected to yield approximately 3,628 acre-ft of water today; about 98% of normal. Average streamflow for this time of year is 1,861 cfs, with recent peaks last observed on 2022-05-27 when daily discharge volume was observed at 43,830 cfs.

Maximum discharge along the river is currently at the Tuckasegee River At Bryson City reporting a streamflow rate of 1,050 cfs. However, the streamgauge with the highest stage along the river is the Tuckasegee River At Sr 1172 Nr Cullowhee with a gauge stage of 5.14 ft. This river is monitored from 3 different streamgauging stations along the Tuckasegee River, the highest being situated at an altitude of 2,116 ft, the Tuckasegee River At Sr 1172 Nr Cullowhee.

The Tuckasegee River is an important natural resource in western North Carolina, stretching 50 miles from its headwaters in the Great Smoky Mountains National Park to its confluence with the Little Tennessee River. Historically, the river played a significant role in Cherokee culture and served as a source of food and transportation for early settlers. Today, the river supports a variety of recreational activities, including fishing, kayaking, and tubing. The river's hydrology is impacted by several large reservoirs, including Lake Glenville, Bear Creek Lake, and Fontana Lake, which was created by the Fontana Dam, the tallest dam east of the Rocky Mountains. These reservoirs provide hydroelectric power, flood control, and water supply for residents and industries in the region. Additionally, the Tuckasegee River Valley is home to several farms and vineyards, which benefit from the river's fertile soils and abundant water supply.