The town is situated near the headwaters of the Wolf River, which is a major tributary of the Mississippi River. The hydrology of the area includes streams, rivers, lakes, and wetlands that provide important habitat for fish and wildlife. Outdoor recreation opportunities in Enville and the surrounding area include fishing, boating, hiking, and wildlife watching. The nearby Chickasaw National Wildlife Refuge offers visitors a chance to explore thousands of acres of wetlands and bottomland forests, home to a variety of waterfowl, songbirds, and other wildlife species.
Enville receives approximately 1401mm of rain per year, with humidity levels near 89% and air temperatures averaging around 16°C. Enville has a plant hardyness factor of 7, meaning plants and agriculture in this region tend to thrive during the non-winter months.