The Trail of Tears State Park camping area in Missouri offers scenic views of the Mississippi River and the surrounding bluffs. Nearby points of interest include the historic town of Cape Girardeau and the Bollinger Mill State Historic Site. The campground amenities include flush toilets, hot showers, and picnic areas. The campsites are available on a first-come, first-serve basis and there are a total of 80 campsites.

An interesting fact about the Trail of Tears State Park is that it commemorates the forced removal of the Cherokee Nation from their homeland in the southeastern United States to Indian Territory (present-day Oklahoma) in 1838-1839. The park's interpretive center offers educational displays and exhibits about this dark chapter in American history.

The best time of year to visit the Trail of Tears State Park camping area is in the fall when the trees are changing colors and the temperatures are mild. The average temperature in October is around 65°F during the day and 43°F at night. However, the park is open year-round and visitors can enjoy activities such as hiking, fishing, and boating during the warmer months.