Doe Run, Missouri is located in the southeastern part of the state, with a humid subtropical climate characterized by hot summers and mild winters. The region is known for its high levels of lead and other heavy metals, which are a result of historical mining operations. The hydrology constituents in the area are closely monitored due to the potential impact on water quality, and efforts have been made to mitigate any negative effects on local ecosystems. Outdoor recreation opportunities in Doe Run include hiking and birdwatching in the nearby St. Francois State Park, as well as fishing and boating on the Mississippi River.