Drexel, Missouri has a humid continental climate with hot summers and cold winters. The town is situated along the Muddy Creek, a tributary of the Marais des Cygnes River. The water quality of the creek is monitored by the Missouri Department of Natural Resources and is considered impaired due to high levels of bacteria and sediment. However, nearby outdoor recreation opportunities include hunting, fishing, and hiking in the Conservation Department's Four Rivers Conservation Area, which includes wetlands and forested areas. Additionally, the Drexel City Park features a playground, picnic area, and sports fields.