Holcomb, Mississippi is a small town located in the northern part of the state. It experiences a humid subtropical climate with hot, humid summers and mild winters. Average temperatures range from the mid-80s Fahrenheit in summer to the mid-40s in winter. The area receives an average annual rainfall of around 55 inches.

Hydrology constituents in Holcomb consist of several small streams and creeks that flow through the town. These waterways contribute to the overall hydrological system of the region, ultimately draining into the nearby Yalobusha River. The town also has access to groundwater sources, primarily from wells.

For outdoor recreation enthusiasts, Holcomb offers a range of opportunities. The nearby Enid Lake, just a short drive away, provides excellent fishing and boating opportunities. The lake is known for its abundant catfish, crappie, and bass. There are also opportunities for camping, hiking, and birdwatching in the surrounding forests and natural areas. The Holcomb Recreation Area is a popular spot for picnics and family gatherings, offering playgrounds, pavilions, and sports fields. With its mild climate and natural beauty, Holcomb provides ample opportunities for residents and visitors to enjoy the outdoors.