Kampsville, Illinois is a small village located in Calhoun County, situated along the banks of the Illinois River. The region experiences a humid continental climate characterized by four distinct seasons. Summers are hot and humid, with average temperatures reaching the low 90s°F (around 32°C), while winters can be cold, with temperatures dropping to the mid-20s°F (around -4°C). Spring and autumn offer mild and pleasant weather.

Being situated on the Illinois River, hydrology plays a significant role in Kampsville. The river provides ample opportunities for various water-based activities, such as boating, fishing, and kayaking. The area is also known for its diverse ecosystem, with wetlands and floodplains supporting a rich variety of plant and animal life.

Kampsville offers numerous outdoor recreation opportunities. The nearby Pere Marquette State Park features hiking trails with breathtaking views of the river valley, while the Two Rivers National Wildlife Refuge offers nature trails and excellent bird-watching opportunities. Additionally, the region is home to several campgrounds and picnic areas, providing visitors with a chance to immerse themselves in the scenic beauty of the area.