Mayview, Missouri is located in Lafayette County, in the central part of the state. The town experiences a humid continental climate, with hot summers and cold winters. Summers are typically warm and humid, with average temperatures ranging from the mid-70s to low 90s Fahrenheit. Winters are cold, with average temperatures in the mid-20s to low 40s Fahrenheit. Precipitation is evenly distributed throughout the year, with Mayview receiving around 40 inches of rainfall annually.

Mayview is surrounded by beautiful natural landscapes, with several outdoor recreation opportunities for residents and visitors. The town is located near several rivers and lakes, including the Missouri River and Big Lake. These waterbodies offer opportunities for boating, fishing, and water sports. There are also several parks and nature reserves in the area, providing hiking and camping options. Conservation areas, such as the Burr Oak Woods Nature Center, offer educational programs and trails for nature enthusiasts. Mayview offers a variety of outdoor activities, making it an appealing destination for those who enjoy nature and outdoor recreation.