Mouth of Wilson is a small unincorporated community located in Grayson County, Virginia. Situated in the Appalachian Mountains, it offers a picturesque landscape and a serene environment. The climate in Mouth of Wilson is classified as humid subtropical, characterized by warm summers and mild winters. Average temperatures range from the mid-80s°F (30°C) in summer to the mid-30s°F (2°C) in winter.

The community is surrounded by various water sources, including the New River, Big Wilson Creek, and Little Wilson Creek. These waterways provide numerous hydrology constituents, such as diverse aquatic species and lush vegetation. Outdoor enthusiasts can enjoy fishing, kayaking, and canoeing in the New River, which is renowned for its scenic beauty and excellent fishing opportunities.

Mouth of Wilson also offers a variety of outdoor recreational activities. The nearby Grayson Highlands State Park boasts stunning vistas, hiking trails, and camping facilities. Visitors can explore the renowned Mount Rogers National Recreation Area, known for its diverse flora and fauna, extensive trail network, and opportunities for horseback riding. The area's abundant wildlife, including white-tailed deer and wild ponies, adds to the allure of outdoor adventures in Mouth of Wilson.