Santa Fe, Missouri is a charming town located in the heart of the state. It enjoys a humid continental climate, characterized by hot summers and cold winters. Summers are generally warm, with temperatures averaging around 85°F, while winters can be quite chilly, with temperatures dropping to around 30°F. The region experiences moderate rainfall throughout the year.

Hydrologically, Santa Fe is home to the majestic Santa Fe River, which flows through the town. The river not only adds to the scenic beauty but also offers various recreational opportunities. Fishing enthusiasts can try their luck at catching bass, catfish, and other species that inhabit these waters. Additionally, kayaking and canoeing are popular activities, allowing visitors to explore the river's picturesque surroundings.

Santa Fe boasts a range of outdoor recreation opportunities. The town is nestled in an area rich in natural beauty, with nearby forests and parks providing ample opportunities for hiking, camping, and wildlife spotting. There are also several trails for biking and horseback riding, allowing visitors to immerse themselves in the serene countryside. With its pleasant climate, beautiful hydrology, and diverse outdoor activities, Santa Fe, Missouri is a destination that offers something for everyone.