The Oh Be Joyful River Run in Colorado on the Gunnison River is a challenging Class III-IV section of water with several obstacles to navigate, including tight channels and boulder gardens. The best time to float this section is in late spring or early summer when the snowmelt provides optimal flow, with recommended CFS between 800-1200. It is important to note that this run is not recommended for beginners or those without strong whitewater experience. Overall, the Oh Be Joyful River Run is a thrilling adventure for experienced kayakers and rafters seeking a challenging and scenic ride.