The Whitewater River Run begins below the Youghiogheny River Lake Dam in Confluence, Pennsylvania and ends in South Connellsville, Pennsylvania. The ideal streamflow range for this run is between 800-2000 cubic feet per second (cfs), which is usually present in spring and early summer due to snowmelt and rainfall. The class rating for this run is generally considered to be between Class III and IV.

The segment mileage of this run is approximately 11 miles, and it is known for its challenging rapids and obstacles including the Cucumber Falls, Dimple Rock, and the Cheeseman's Eddy. The rapids on this run are characterized by strong currents, tight channels, and exposed rocks, making it a popular destination for experienced whitewater enthusiasts.

There are specific regulations to the area that must be followed, including wearing a personal flotation device (PFD) at all times, carrying a whistle or signaling device, and following Leave No Trace principles to protect the natural environment. Additionally, all participants must be at least 12 years old and have prior experience in Class II whitewater or higher.