The Whitewater River Run from the Confluence of North and South Forks of Twisp River to Lake Chelan-Sawtooth Wilderness Boundary in Washington State is a Class III-IV river run, with an ideal streamflow range of 1000-2000 cfs. The segment mileage is approximately 13.5 miles and includes several notable rapids and obstacles, such as the Twisp River Falls, which is a Class IV rapid.

Other notable rapids include the Root Canal, a Class III+ rapid, and the Drop Zone, a Class III rapid. The river run also features several scenic sections where paddlers can take in the natural beauty of the area.

Regulations for the Whitewater River Run include a permit system through the U.S. Forest Service, which limits the number of paddlers on the river at any given time. Additionally, the use of motorized watercraft is prohibited, and all paddlers must wear personal flotation devices and helmets.

Overall, the Whitewater River Run is a challenging and rewarding river run for experienced paddlers looking for a thrilling adventure in a pristine wilderness setting.