The Gypsum Creek run on the Whitewater River in Wyoming is a popular destination for whitewater enthusiasts. The ideal streamflow range for this run is between 250 and 800 cfs. The Gypsum Creek section of the river is rated as a class III-IV section, which means that it is considered to be a challenging run for experienced paddlers.

The segment mileage for this run is approximately 9 miles, and it features several notable rapids and obstacles. One of the most prominent rapids on the Gypsum Creek run is called "The Ledge," which is a technical rapid that requires precise navigation. Other notable rapids include "Kittle's Revenge" and "Dead Dog."

There are several regulations that apply to the Gypsum Creek run. All boaters are required to wear a personal flotation device (PFD) at all times while on the river, and all boaters must also have a whistle and a throw bag. Additionally, there are restrictions on the use of motors on the river, and camping and fires are only allowed in designated areas.