Medicine Lodge Creek is a tributary of the Wind River, located in the Washakie Wilderness of Wyoming. The ideal streamflow range for this river is between 300-800 cfs, which usually occurs during late spring to early summer. The river is rated a Class III-V, with a total segment mileage of 20 miles.

The river features a number of notable rapids, including the "Notch," "Medicine Lodge Falls," and the "Box." The Notch is a steep, narrow drop that requires precise maneuvering, while Medicine Lodge Falls is a 20-foot drop that can be challenging for even experienced kayakers. The Box is a narrow canyon that requires technical paddling skills.

There are specific regulations for the area, including a requirement to obtain a permit for overnight camping and a restriction on the use of fires above 9,000 feet. Additionally, the Washakie Wilderness area is protected, and visitors are encouraged to follow Leave No Trace principles to minimize their impact on the environment.