Maximum discharge along the river is currently at the reporting a streamflow rate of cfs. This is also the highest stage along the Mayo River, with a gauge stage of ft at this location. This river is monitored from 1 different streamgauging stations along the Mayo River, the highest being situated at an altitude of ft, the .

The Mayo River in North Carolina has a rich history dating back to early Native American settlements. It is approximately 64 miles long, flowing through Rockingham, Stokes, and Henry counties. The river is fed by several smaller streams and is known for its unique hydrology, including rapids and waterfalls. It is home to several reservoirs and dams, including the Belews Lake Dam, which serves as a major source of hydroelectric power for the region. The river is also used for agriculture, with farms and pastures lining its banks. Additionally, it is a popular recreational spot for fishing, kayaking, and tubing. In recent years, conservation efforts have been implemented to maintain and improve the river's ecological health.