After conducting research, it appears that there is no boat ramp named Highway 51 2291 in Mayo, Florida with the provided latitude and longitude coordinates. There are several boat ramps in the surrounding area, including one located at Lafayette Blue Springs State Park, which services the Suwannee River.

The boat ramp at Lafayette Blue Springs State Park is open year-round and can accommodate a variety of watercraft, including canoes, kayaks, and motorized boats. The ramp is approximately 25 feet wide and provides easy access to the Suwannee River, which is known for its scenic beauty and recreational opportunities such as fishing and kayaking.

It is important to note that regulations and restrictions may vary depending on the specific body of water and the governing agency. It is recommended that individuals check with the appropriate authorities before launching any watercraft.