It services the Grand Lake o' the Cherokees, which is a popular recreational lake in northeast Oklahoma. The body of water is open to a variety of watercraft, including powerboats, sailboats, kayaks, and canoes. There are no restrictions on the type of watercraft that can be launched from the E0420 Road Mayes County boat ramp, but all boats must comply with state and federal regulations regarding safety equipment, registration, and boating under the influence. Overall, the E0420 Road Mayes County boat ramp provides easy access to the Grand Lake o' the Cherokees for boaters and anglers in the Mayes County area.
| NEOSHO RIVER NEAR LANGLEY | 550cfs |
| BIG CABIN CREEK NEAR BIG CABIN | 62cfs |
| SPAVINAW CREEK NEAR EUCHA | 159cfs |
| NEOSHO RIVER NEAR CHOUTEAU | 16000cfs |
| BEATY CREEK NEAR JAY | 12cfs |
| SPAVINAW CREEK NEAR COLCORD | 80cfs |