The Whitewater River run begins at the northern boundary of the Wallowa-Whitman National Forest and runs until it reaches the confluence with the Grande Ronde River in Idaho. The ideal streamflow range for this run is between 1,500 and 3,000 cubic feet per second (cfs). This range provides a good balance between navigability and excitement on the rapids.

The class rating for this run varies depending on the section being navigated. The upper section is considered class IV and V, while the lower section is rated as class III and IV. The total distance of this run is roughly 15 miles.

There are several notable rapids and obstacles along the way, including "Jaws of Death," "Widowmaker," and "Screaming Right Turn." These rapids require a high level of skill and experience to navigate safely.

Specific regulations for this area include a permit system, which limits the number of visitors to the river each day. Additionally, all boaters are required to wear personal flotation devices (PFDs) at all times while on the river.