The Whitewater River Run from Headwaters to Confluence with Vance Creek at Payette NF Boundary is a 7.1-mile stretch that offers Class III-V rapids. The ideal streamflow range for this run is between 600-1800 cfs. The segment mileage includes four distinct sections, with the upper section being the most challenging due to its steep gradient and boulder gardens. The middle section has more continuous rapids and is more technical, while the lower section has larger waves and holes.

Some of the specific rapids and obstacles on this run include "S-Turn," "Tunnel Vision," and "The Sieve." The S-Turn is a series of tight turns through a boulder garden. Tunnel Vision is a narrow chute with a tight right-hand turn at the bottom that requires precise navigation. The Sieve is a dangerous rapid that requires expert-level skills to navigate safely.

Specific regulations for this area include a permit requirement for commercial outfitters and a limit of 12 people per party. Additionally, all boaters must wear a personal flotation device and have a throwable flotation device on board. The use of alcohol and drugs is strictly prohibited on this run.

Overall, the Whitewater River Run from Headwaters to Confluence with Vance Creek at Payette NF Boundary is a challenging and exciting run that requires advanced skills and experience. Boaters should be aware of the specific regulations and safety requirements before embarking on this adventure.