The Whitewater River run begins upstream of the Diversion Dam (Rm 1) and flows for a total of 10.6 miles until it reaches the confluence with the Skagit River in the state of Washington. The ideal streamflow range for this run is between 800-2000 cfs. This flow range provides the best conditions for Class III rapids, which are the main feature of this run. The class rating for this run is Class III-IV.

The segment mileage of the Whitewater River run is broken down into three major sections. The first section, which is 1.5 miles long, is rated as Class II-III. The second section is the longest, at 5.5 miles, and contains the most challenging rapids, rated as Class III-IV. The final section, which is 3.6 miles long, is rated as Class II-III.

Several specific river rapids and obstacles require careful attention on this run. The most notable rapids include the "Flush," "Upper and Lower Zigzag," "Texas Creek Rapid," "Twin Bridges Rapid," "Boulder Drop," and "Final Rapid." Additionally, there are several strainers and sweepers that need to be avoided throughout the run.

Specific regulations to the area include a required permit from the local ranger station. Additionally, boaters must adhere to minimum impact practices, such as packing out all trash and avoiding camping within 200 feet of waterways. Finally, boaters must respect any private property along the river and obtain permission before accessing it.