The Whitewater River run begins at the headwaters in the state of Washington and includes all tributaries up to the confluence with unnamed tributaries. The ideal streamflow range for this river varies depending on the segment being run. The section from the headwaters to the confluence with the North Fork is best run at 400-800 cfs, while the section from the confluence with the North Fork to the confluence with the East Fork is ideal at 800-1200 cfs. The section from the confluence with the East Fork to the confluence with the West Fork is best run at 1200-2000 cfs.

The river is rated as Class III-IV, with some challenging rapids and obstacles for experienced paddlers. The segment from the headwaters to the confluence with the North Fork is 5 miles long, while the section from the confluence with the North Fork to the confluence with the East Fork is 6 miles long. The section from the confluence with the East Fork to the confluence with the West Fork is 7 miles long.

Some of the specific rapids and obstacles on this river include "The Ledge," "The Slot," "The S-Turn," and "The Elevator." These rapids require expert precision and skill to navigate safely.

There are specific regulations in this area that paddlers need to be aware of. A permit is required for all river use, and camping is only allowed in designated areas along the river. Additionally, there are restrictions on the use of motorized boats and other watercraft in certain sections of the river.