The Whitewater River Run begins above Slough Creek Campground, located on a secondary spur road to the park's main road, and flows for approximately 2.5 miles to the confluence with Lamar River in the state of Wyoming. This stretch of river has an ideal streamflow range of 200-600 cfs, providing ample flow for rafting and kayaking. The class rating for this section is Class III, meaning it has moderate rapids with moderate to strong currents, as well as some obstacles that require quick maneuvering.

Along the 2.5-mile stretch of river, paddlers will encounter several notable rapids, including the "Ledges," "House Rock," and "Rock Garden." Each of these rapids offers a unique challenge, with the Ledges featuring a series of narrow channels and House Rock and Rock Garden requiring careful navigation through boulder fields.

To ensure the safety of paddlers and preserve the natural environment, there are specific regulations for the area. For example, boaters must carry a throwable personal flotation device and a sound-producing device. Additionally, it is recommended that paddlers wear a personal flotation device at all times while on the water.

Overall, the Whitewater River Run is an exciting and challenging stretch of river that requires skill and experience to navigate safely. It is important to respect the regulations in place and to always prioritize safety when enjoying this beautiful natural resource.