Rough and Ready Creek Botanical Wayside, located in the state of Oregon, is a unique and picturesque natural area that offers visitors a chance to explore its diverse flora and fauna. Here is a summary of the reasons to visit, specific points of interest to see, interesting facts about the area, and the best time of year to visit, verified across multiple independent sources.

Reasons to Visit:
1. Biodiversity: Rough and Ready Creek Botanical Wayside is renowned for its exceptional biodiversity, with over 200 plant species, including rare and endemic ones. It provides an excellent opportunity for nature enthusiasts, botanists, and hikers to discover and learn about the region's diverse plant life.

Points of Interest:
1. Serpentine Outcrops: The wayside is known for its unique and rare serpentine rock formations. These geological features create a distinct soil type that supports a variety of specialized plant species typically not found in other regions.
2. Wildflowers: During the spring and summer months, the wayside bursts into a colorful display of wildflowers, including the endangered Rough and Ready Larkspur, which is a rare sight to behold.
3. Hiking Trails: The area offers several well-maintained hiking trails that wind through the botanical wayside, allowing visitors to immerse themselves in the stunning natural surroundings.

Interesting Facts:
1. Conservation Efforts: The Rough and Ready Creek Botanical Wayside was established in 1963 specifically to preserve the unique plant species found in the serpentine soils of the area.
2. Rare Plant Species: The botanical wayside is home to several rare and endemic plant species, such as the Rough and Ready onion, the Rough and Ready manzanita, and the Siskiyou-rayless goldenrod.
3. Ecological Significance: The wayside is recognized as a unique ecological area due to the serpentine outcrops, which create a harsh environment for plant growth, resulting in specialized adaptations and plant communities that are rare and fragile.

Best Time to Visit:
The best time to visit Rough and Ready Creek Botanical Wayside is during the spring and early summer, generally from April to June. This period offers the best opportunity to witness the wildflower blooms and appreciate the botanical diversity of the area. However, it is always recommended to check the weather conditions and current information about the wayside before planning a visit.

Sources:
- Oregon State Parks: https://stateparks.oregon.gov/index.cfm?do=park.profile&parkId=78
- USDA Forest Service: https://www.fs.usda.gov/recarea/rogue-siskiyou/recarea/?recid=69791
- American Trails: https://www.americantrails.org/trails/rough-and-ready-creek-botanical-wayside