Anglers can expect to catch largemouth bass, bluegill, crappie, and catfish. The area also offers a variety of activities, such as boating, kayaking, and birdwatching. For fishing, it's best to use live bait or lures that mimic native prey. The best time to visit is in the winter months, from December to February, with average temperatures ranging from 50-70°F. Overall, Lake Panasoffkee is a great spot for anglers and outdoor enthusiasts looking for a peaceful escape in the heart of Florida.