The Whitewater River run from Headwaters in Standing Indian Basin to Slackwater of Natahala Lake in North Carolina is a popular destination for kayakers, rafters, and canoeists. The ideal streamflow range for this run is between 250 and 800 cubic feet per second (cfs), with 400 cfs being the optimal level. The segment mileage for this run is approximately 13 miles, and it is rated as a class III-IV river, with some rapids approaching class V.

Some of the specific rapids and obstacles on this run include the S-Turn rapid, the Corkscrew rapid, the Brainard's Bridge rapid, and the Final Curtain rapid. These rapids can be challenging, with steep drops, tight turns, and powerful currents. Participants should have proper gear, experience, and knowledge of the area before attempting this run.

There are specific regulations and guidelines in place for this area to ensure the safety of all participants. These include wearing a personal flotation device (PFD) at all times, obeying all posted signs and warnings, and obtaining necessary permits and licenses before entering the area. Additionally, participants should practice Leave No Trace principles and respect the natural environment.