The Nantahala River run from the Nantahala Powerhouse to Lake Fontana (River Mile 4) in North Carolina is a popular whitewater rafting destination. The ideal streamflow range for this segment is between 1,000 and 3,000 cubic feet per second (cfs). The segment spans 8 miles and is rated as a Class II-III rapids, making it suitable for intermediate-level paddlers.

There are several notable rapids and obstacles on this stretch of the river. The most famous is the Nantahala Falls, which is a Class III rapid that features a 6-foot drop and a large hydraulic at the bottom. Other notable rapids include the Quarry Rapid and the Surfing Rapid.

There are specific regulations in place for this area. All boaters must obtain a permit from the Nantahala National Forest Service, and there are restrictions on the number of commercial outfitters allowed to operate on the river. Additionally, all boaters must wear a personal flotation device (PFD) and helmets are strongly recommended.

Overall, the Nantahala River run from the Nantahala Powerhouse to Lake Fontana is a popular and exciting whitewater destination for intermediate-level paddlers. It offers a variety of rapids and obstacles, and the regulations in place help to ensure that the area is safe for all visitors.