Mission Hills, located in the San Fernando Valley of Los Angeles, California, enjoys a Mediterranean climate characterized by warm, dry summers and mild, wet winters. Summers can see temperatures ranging from the mid-70s to mid-90s Fahrenheit (24-35°C), while winters average in the 50s and 60s Fahrenheit (10-15°C). The region experiences limited rainfall, with most precipitation occurring between November and March.

Hydrologically, Mission Hills is part of the Los Angeles River watershed, which includes the Pacoima Wash and the Tujunga Wash. These waterways provide important drainage for the area but are largely channelized due to flood control measures. They also support some riparian habitat and are popular among birdwatchers and nature enthusiasts.

Outdoor recreation opportunities in Mission Hills and its surrounding areas include hiking, biking, and horseback riding in nearby parks like O'Melveny Park and Hansen Dam Recreation Area. Within a short drive, residents can access the Santa Monica Mountains, offering stunning hiking trails, scenic overlooks, and opportunities for wildlife spotting. Additionally, Mission Hills's proximity to the coast allows for convenient beach visits, where water activities such as swimming, surfing, and sunbathing can be enjoyed.