Mississippi offers a diverse range of freshwater and saltwater fishing opportunities. Popular angling destinations in the state include the Mississippi River, Sardis Lake, Ross Barnett Reservoir, and Gulf of Mexico. The state is home to a variety of species of fish, including largemouth bass, crappie, catfish, bream, redfish, and speckled trout. The best times of year to fish in Mississippi vary depending on the species and location, but generally, spring and fall are the most productive times. Average seasonal temperatures range from the 40s in winter to the 90s in summer.

For freshwater fishing, anglers should use bait or lures that mimic the natural prey of the fish they are targeting. For example, bass can be caught using plastic worms or spinnerbaits, while crappie can be caught using small jigs or minnows. For saltwater fishing, live bait such as shrimp or mullet is often the most effective.

Interesting fishing facts about Mississippi include the fact that the state record for largemouth bass is over 18 pounds, and the state is home to the largest oxbow lake in the United States, which is the 47,000-acre Arkabutla Lake. Mississippi also offers anglers the opportunity to fish for alligator gar, which can weigh over 100 pounds.