The Whitewater River Run in California is a popular spot for experienced whitewater enthusiasts. The ideal streamflow range for this run is between 200 and 1000 cubic feet per second (cfs). The class rating of the run is between III and V, with some challenging obstacles, such as the "Meatgrinder" and "Souse Hole".

The segment mileage of the run is approximately 14 miles, starting at the confluence of Lone Pine and Hamilton (Deer) Creeks, and extending to the wilderness boundary. The river rapids and obstacles vary throughout the run, with some sections requiring technical skill and others providing thrilling waves and drops.

Regulations for the area include a boundary extend of 0.25 mile on each side of the river, which is strictly enforced to protect the wilderness area. All visitors must obtain a permit from the Bureau of Land Management and follow Leave No Trace principles to minimize impact on the ecosystem.