The Headwaters To Holy Cross Wilderness Boundary run on the Whitewater River in Colorado is ideal for intermediate to advanced rafters. With a class rating of III-IV, this run spans a distance of 22 miles and features several notable rapids and obstacles. The ideal streamflow range for the Whitewater River is between 500 and 2500 cfs, which generally occurs during the spring runoff season from April to June.

Some of the more notable rapids on this stretch of the Whitewater River include Corkscrew, Guide's Revenge, and Sledgehammer. These rapids feature technical maneuvers and require precise navigation by the rafter. Other obstacles on this run include rocks, drops, and narrow channels.

In terms of regulations, the Whitewater River is managed by the Bureau of Land Management, which requires all rafters to obtain a permit before launching. Additionally, all rafters are required to wear a personal flotation device and follow Leave No Trace principles to minimize the impact on the environment.

Overall, the Headwaters To Holy Cross Wilderness Boundary run on the Whitewater River in Colorado offers a thrilling and challenging experience for rafters who are looking for a technical and scenic whitewater adventure.