The Whitewater River Run, from Open Creek Source to Confluence with Thorofare in Wyoming, is a popular destination for kayakers and rafters seeking exciting rapids and scenic views. The ideal streamflow range for this run is between 200-1000 cfs, with higher flows providing more challenging rapids. The segment mileage for this run is around 12 miles, with the class rating ranging from Class II to Class IV, depending on the section of the river.

Some notable rapids and obstacles on this run include "Four Mile Rapid," "Northwest Passage," and "Big Drop Rapid," which all offer exhilarating drops and technical maneuvers. This run also features stunning views of the surrounding wilderness, with opportunities for wildlife sightings and photography.

There are specific regulations to be aware of when planning a trip to the Whitewater River Run. The area is located within Yellowstone National Park, and therefore, visitors must obtain a backcountry permit before launching their boats. Additionally, visitors must follow Leave No Trace principles and pack out all waste. It's also important to note that motorized boats are not permitted on this section of the river.

Overall, the Whitewater River Run is a must-do for experienced kayakers and rafters seeking a thrilling adventure in a beautiful wilderness setting. However, visitors should always check the current streamflow conditions and be prepared for changing weather and river conditions.