The Whitewater River run from Headwaters to Confluence with Nelson Creek in California is a popular destination for whitewater rafting enthusiasts. The ideal streamflow range for this segment is between 400 and 800 cubic feet per second (cfs) during the spring and early summer months. This segment is rated as a class III to IV, which means that it has a moderate to difficult level of difficulty with moderate to high risk. The segment covers a distance of approximately 12 miles and is known for its fast-paced rapids and obstacles, including the Shotgun, Pinball, and Sledgehammer.

There are specific regulations for the area, including the requirement of a permit to access the river. The permit is issued by the Bureau of Land Management and can be obtained online or at designated locations. Additionally, all participants must wear appropriate safety gear, including a helmet and a personal flotation device. The river is considered a protected area, and visitors are expected to respect and preserve the natural environment.