The Whitewater River Run from Tie Canyon to Targhee NF Boundary is a popular destination for whitewater rafters in Idaho. The ideal streamflow range for this section of the river is between 1500 and 3000 cfs, with the peak season running from May to June. The class rating for this stretch of the river is a Class III-IV, meaning it is suitable for intermediate to advanced rafters. The total segment mileage is approximately 9 miles, with several notable rapids and obstacles along the way.

Some of the most significant rapids on this section of the Whitewater River Run include The Jaws, which is a Class IV rapid with a narrow chute and a large boulder blocking the way. Other notable rapids include Mixmaster, a technical Class III rapid that requires precise maneuvering, and T-Bone, a Class III+ rapid with a large boulder in the middle of the river.

Specific regulations to the area include a required permit for commercial rafting companies, and a limit of 12 people per raft. Additionally, all participants must wear a personal flotation device at all times while on the river.