The Whitewater River Run from Confluence with Guest River to Confluence with Little Stony Creek in Virginia is a popular destination for whitewater enthusiasts. The ideal streamflow range for this segment is between 800 and 2000 cfs, with peak season in the spring and fall. The class rating for this stretch of the river varies between Class II and Class III rapids, with some particularly challenging sections.

The total segment mileage for this run is approximately 12 miles. There are several notable rapids and obstacles along the way, including Rough Run, a long Class III rapid with multiple drops and large waves. Another difficult section is the Narrows, a narrow and rocky gorge with Class III rapids.

There are specific regulations to be aware of when planning a trip to this area. A permit is required to access the river, and all visitors must follow Leave No Trace principles. Additionally, there are fishing regulations in place to protect local species. It is important to check with local authorities to ensure compliance with all regulations.